DISEASES

Disease-gene associations mined from literature

Literature associating POLR2M and typhus

POLR2M [ENSP00000299638]

DNA-directed RNA polymerase II subunit GRINL1A; Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. ; Belongs to the GRINL1 family.

Synonyms:  POLR2M,  POLR2Mp,  hPOLR2M,  E9PP13,  GRINL1A ...

Linkouts:  STRING  Pharos  UniProt