DISEASES

Disease-gene associations mined from literature

Literature associating FOLR2 and thymus sarcomatoid carcinoma

FOLR2 [ENSP00000298223]

Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Synonyms:  FOLR2,  FOLR2p,  hFOLR2,  A0A087WWY2,  E7EU04 ...

Linkouts:  STRING  Pharos  UniProt  OMIM