DISEASES

Disease-gene associations mined from literature

Literature associating HSD3B7 and liver disease

HSD3B7 [ENSP00000297679]

3 beta-hydroxysteroid dehydrogenase type 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis . Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.

Synonyms:  HSD3B7,  HSD3B7p,  hHSD3B7,  I3L2H6,  I3L2Q9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM