DISEASES

Disease-gene associations mined from literature

Literature associating SUN3 and autosomal recessive nonsyndromic deafness 40

SUN3 [ENSP00000297325]

SUN domain-containing protein 3; As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.

Synonyms:  SUN3,  SUN3p,  hSUN3,  A0A0A0MSG9,  F8WDT4 ...

Linkouts:  STRING  Pharos  UniProt