DISEASES

Disease-gene associations mined from literature

Literature associating NKX6-1 and neonatal diabetes

NKX6-1 [ENSP00000295886]

Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).

Synonyms:  NKX6-1,  F8VWZ9,  P78426,  F8VWZ9p,  hF8VWZ9 ...

Linkouts:  STRING  Pharos  UniProt