DISEASES

Disease-gene associations mined from literature

Literature associating HPGDS and inflammatory bowel disease 16

HPGDS [ENSP00000295256]

Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279,; Belongs to the GST superfamily. Sigma family.

Synonyms:  HPGDS,  A0A384P5J0,  O60760,  O60760p,  hO60760 ...

Linkouts:  STRING  Pharos  UniProt  OMIM