DISEASES

Disease-gene associations mined from literature

Literature associating MEMO1 and X-linked cleft palate with or without ankyloglossia

MEMO1 [ENSP00000295065]

Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

Synonyms:  MEMO1,  MEMO1p,  hMEMO1,  B5MCI6,  C9JSD7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM