DISEASES

Disease-gene associations mined from literature

Literature associating FGF19 and extrahepatic cholestasis

FGF19 [ENSP00000294312]

Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. ; Belongs to the heparin-binding growth factors family.

Synonyms:  FGF19,  FGF19p,  hFGF19,  O95750,  O95750p ...

Linkouts:  STRING  Pharos  UniProt  OMIM