DISEASES

Disease-gene associations mined from literature

Literature associating BAX and colorectal cancer

BAX [ENSP00000293288]

Apoptosis regulator BAX; Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) . Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:21458670, ECO:0000269|PubMed:8358790,

Synonyms:  H0YA56,  I6LPK7,  K4JQN1,  Q07812,  H0YA56p ...

Linkouts:  STRING  Pharos  UniProt  OMIM