DISEASES

Disease-gene associations mined from literature

Literature associating CCR2 and rhinoscleroma

CCR2 [ENSP00000292301]

C-C chemokine receptor type 2; Key functional receptor for CCL2 but can also bind CCL7 and CCL12 . Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B . Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). ECO:0000269|PubMed:23938203, ECO:0000269|PubMed:8048929,

Synonyms:  CCR2,  CCR2p,  hCCR2,  A0A024R2Q0,  E9PH76 ...

Linkouts:  STRING  Pharos  UniProt  OMIM