DISEASES

Disease-gene associations mined from literature

Literature associating SPPL3 and Plasmodium ovale malaria

SPPL3 [ENSP00000288680]

Signal peptide peptidase-like 3; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis . May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 . Plays a role in the regulation of cellular glycosylation processes . Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease- independent manner . ECO:0000269|PubMed:23132852, ECO:0000269|PubMed:25354954,; Belongs to the peptidase A22B family.

Synonyms:  SPPL3,  SPPL3p,  hSPPL3,  F5H2A2,  F5H4L1 ...

Linkouts:  STRING  Pharos  UniProt