DISEASES

Disease-gene associations mined from literature

Literature associating ITGB6 and dental enamel hypoplasia

ITGB6 [ENSP00000283249]

Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin . It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion . ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 . Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G- D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607, (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 .

Synonyms:  ITGB6,  ITGB6p,  hITGB6,  A0A087WXP3,  E9PEE8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM