DISEASES

Disease-gene associations mined from literature

Literature associating RANBP2 and inflammatory myofibroblastic tumor

RANBP2 [ENSP00000283195]

E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates . Binds single-stranded RNA (in vitro) . May bind DNA . Component of the nuclear export pathway . Specific docking site for the nuclear export factor exportin-1 . Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB . Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle . Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity . ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:23353830,

Synonyms:  RANBP2,  RANBP2p,  hRANBP2,  F8WBP7,  P49792 ...

Linkouts:  STRING  Pharos  UniProt  OMIM