DISEASES

Disease-gene associations mined from literature

Literature associating PRDM15 and Galloway-Mowat syndrome

PRDM15 [ENSP00000269844]

PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming .

Synonyms:  PRDM15,  PRDM15p,  hPRDM15,  E7ER26,  P57071 ...

Linkouts:  STRING  Pharos  UniProt