DISEASES

Disease-gene associations mined from literature

Literature associating OLFM2 and arteriosclerosis obliterans

OLFM2 [ENSP00000264833]

Noelin-2; Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes . Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).

Synonyms:  OLFM2,  OLFM2p,  hOLFM2,  K7EIS8,  K7EKW2 ...

Linkouts:  STRING  Pharos  UniProt