DISEASES

Disease-gene associations mined from literature

Literature associating GPN1 and xeroderma pigmentosum group A

GPN1 [ENSP00000264718]

GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) . May act at an RNAP assembly step prior to nuclear import . Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation . May be involved in nuclear localization of XPA . ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307,

Synonyms:  GPN1,  GPN1p,  hGPN1,  F8WD09,  MBDin ...

Linkouts:  STRING  Pharos  UniProt