DISEASES

Disease-gene associations mined from literature

Literature associating IL1RL2 and Diamond-Blackfan anemia 1

IL1RL2 [ENSP00000264257]

Interleukin-1 receptor-like 2; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Synonyms:  IL1RL2,  IL1RL2p,  hIL1RL2,  C9K0I8,  Q9HB29 ...

Linkouts:  STRING  Pharos  UniProt  OMIM