Literature associating IL1RL2 and familial cold autoinflammatory syndrome 2
IL1RL2 [ENSP00000264257]
Interleukin-1 receptor-like 2; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Synonyms: IL1RL2, IL1RL2p, hIL1RL2, C9K0I8, Q9HB29 ...