DISEASES

Disease-gene associations mined from literature

Literature associating ITGA2B and thrombocytopenia

ITGA2B [ENSP00000262407]

Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Synonyms:  ITGA2B,  ITGA2Bp,  hITGA2B,  A0A3B3IU79,  K7EP83 ...

Linkouts:  STRING  Pharos  UniProt  OMIM