DISEASES

Disease-gene associations mined from literature

Literature associating INTS13 and bone giant cell tumor

INTS13 [ENSP00000261191]

Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing . ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:23097494,

Synonyms:  INTS13,  INTS13p,  hINTS13,  F5H457,  F5H5W1 ...

Linkouts:  STRING  Pharos  UniProt