DISEASES

Disease-gene associations mined from literature

Literature associating RTCA and retinitis pigmentosa 40

RTCA [ENSP00000260563]

RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing; Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.

Synonyms:  RTCA,  A6NIC1,  O00442,  A6NIC1p,  hA6NIC1 ...

Linkouts:  STRING  Pharos  UniProt