DISEASES

Disease-gene associations mined from literature

Literature associating CCL21 and secondary progressive multiple sclerosis

CCL21 [ENSP00000259607]

C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Synonyms:  CCL21,  CCL21p,  hCCL21,  O00585,  Q5VZ73 ...

Linkouts:  STRING  Pharos  UniProt  OMIM