DISEASES

Disease-gene associations mined from literature

Literature associating RGS8 and spinocerebellar ataxia type 1

RGS8 [ENSP00000258302]

Regulator of G-protein signaling 8; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).

Synonyms:  RGS8,  RGS8p,  hRGS8,  D6RD36,  P57771 ...

Linkouts:  STRING  Pharos  UniProt  OMIM