DISEASES

Disease-gene associations mined from literature

Literature associating MRAP2 and Blount's disease

MRAP2 [ENSP00000257776]

Melanocortin-2 receptor accessory protein 2; Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand- sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.

Synonyms:  MRAP2,  MRAP2p,  hMRAP2,  Q96G30,  Q96G30p ...

Linkouts:  STRING  Pharos  UniProt  OMIM