DISEASES

Disease-gene associations mined from literature

Literature associating GDF15 and congenital dyserythropoietic anemia type I

GDF15 [ENSP00000252809]

Growth/differentiation factor 15; Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL- expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions . On hepatocytes, inhibits growth hormone signaling (By similarity). ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886,

Synonyms:  GDF15,  GDF15p,  hGDF15,  A0A0A0MTT8,  Q99988 ...

Linkouts:  STRING  Pharos  UniProt  OMIM