DISEASES

Disease-gene associations mined from literature

Literature associating TSG101 and breast carcinoma

TSG101 [ENSP00000251968]

Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan . It may also play a role in the extracellular release of microvesicles that differ from the exosomes . ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426,; Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

Synonyms:  TSG101,  TSG101p,  hTSG101,  F5H442,  J3QKS4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM