DISEASES

Disease-gene associations mined from literature

Literature associating PTPN12 and leiomyomatosis

PTPN12 [ENSP00000248594]

Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades . Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' .

Synonyms:  PTPN12,  PTPN12p,  hPTPN12,  C9J1X8,  C9JJC1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM