DISEASES

Disease-gene associations mined from literature

Literature associating TICAM1 and pertussis

TICAM1 [ENSP00000248244]

TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis . Ligand binding to these receptors results in TRIF recruitment through its TIR domain . Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively . Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens . Component of a multi-helicase- TICAM1 complex that acts as a cytoplasmic sensor of viral double- stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity). ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043,

Synonyms:  TICAM1,  TICAM1p,  hTICAM1,  A0A087WVI8,  Q8IUC6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM