DISEASES

Disease-gene associations mined from literature

Literature associating SLURP1 and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3

SLURP1 [ENSP00000246515]

Secreted Ly-6/uPAR-related protein 1; Has an antitumor activity . Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin . In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner . In T cells may be involved in regulation of intracellular Ca(2+) signaling . Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation . ECO:0000269|PubMed:17286989, ECO:0000269|PubMed:26905431, ECO:0000269|PubMed:8742060, ECO:0000305|PubMed:14721776,

Synonyms:  SLURP1,  SLURP1p,  hSLURP1,  P55000,  P55000p ...

Linkouts:  STRING  Pharos  UniProt  OMIM