DISEASES

Disease-gene associations mined from literature

Literature associating PLCG1 and angiosarcoma

PLCG1 [ENSP00000244007]

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

Synonyms:  PLCG1,  PLCG1p,  hPLCG1,  A0A0D9SEK2,  M0QX77 ...

Linkouts:  STRING  Pharos  UniProt  OMIM