Literature associating WASHC3 and hereditary spastic paraplegia 8
WASHC3 [ENSP00000240079]
WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093); Belongs to the CCDC53 family.
Synonyms: WASHC3, WASHC3p, hWASHC3, F5GWI9, F5GXZ4 ...