DISEASES

Disease-gene associations mined from literature

Literature associating RGS2 and anxiety disorder

RGS2 [ENSP00000235382]

Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form . It is involved in the negative regulation of the angiotensin-activated signaling pathway . Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein . ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:19736320, ECO:0000269|PubMed:28784619,

Synonyms:  RGS2,  RGS2p,  hRGS2,  A0A024R939,  P41220 ...

Linkouts:  STRING  Pharos  UniProt  OMIM