Literature associating TRIM23 and Noonan syndrome 5
TRIM23 [ENSP00000231524]
E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes .
Synonyms: TRIM23, TRIM23p, hTRIM23, D6R9E9, D6RBN4 ...