DISEASES

Disease-gene associations mined from literature

Literature associating CDKN1B and ocular cancer

CDKN1B [ENSP00000228872]

Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005,; Belongs to the CDI family.

Synonyms:  CDKN1B,  CDKN1Bp,  hCDKN1B,  E7ES52,  H7C2T1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM