DISEASES

Disease-gene associations mined from literature

Literature associating ASIC2 and autosomal recessive pseudohypoaldosteronism type 1

ASIC2 [ENSP00000225823]

Acid-sensing ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Synonyms:  ASIC2,  ASIC2p,  hASIC2,  Q16515,  Q16515p ...

Linkouts:  STRING  Pharos  UniProt