DISEASES

Disease-gene associations mined from literature

Literature associating FIS1 and optic nerve disease

FIS1 [ENSP00000223136]

Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981,; Belongs to the FIS1 family.

Synonyms:  FIS1,  FIS1p,  hFIS1,  C9JXH1,  F5H509 ...

Linkouts:  STRING  Pharos  UniProt  OMIM