DISEASES

Disease-gene associations mined from literature

Literature associating ORC6 and Seckel syndrome

ORC6 [ENSP00000219097]

Origin recognition complex subunit 6; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Synonyms:  ORC6,  ORC6p,  hORC6,  A0A024R6R3,  H3BMA4 ...

Linkouts:  STRING  Pharos  UniProt