DISEASES

Disease-gene associations mined from literature

Literature associating ACOT8 and Flinders Island spotted fever

ACOT8 [ENSP00000217455]

Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH . Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains . Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl- CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). ACOT8 is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation . ECO:0000269|PubMed:15194431, ECO:0000269|PubMed:9153233,; Belongs to the C/M/P thioester hydrolase family.

Synonyms:  ACOT8,  ACOT8p,  hACOT8,  A0A494C0N6,  E9PIS4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM