DISEASES

Disease-gene associations mined from literature

Literature associating VRK1 and syndromic X-linked intellectual disability Najm type

VRK1 [ENSP00000216639]

Serine/threonine-protein kinase VRK1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain- containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336,

Synonyms:  VRK1,  VRK1p,  hVRK1,  H0YJ50,  H0YJF7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM