DISEASES

Disease-gene associations mined from literature

Literature associating PDXP and prolapse of urethra

PDXP [ENSP00000215904]

Pyridoxal phosphate phosphatase; Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine . Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'- phosphate (PMP), with order of substrate preference PLP > PNP > PMP .

Synonyms:  PDXP,  A0A024R1I3,  B1AHD3,  Q96GD0,  B1AHD3p ...

Linkouts:  STRING  Pharos  UniProt  OMIM