DISEASES

Disease-gene associations mined from literature

Literature associating STRADB and congenital myasthenic syndrome 6

STRADB [ENSP00000194530]

STE20-related kinase adapter protein beta; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).

Synonyms:  STRADB,  A0A024R420,  ALS2CR2,  C9JSU7,  F8WCQ7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM