DISEASES

Disease-gene associations mined from literature

Literature associating MAP2K5 and Caroli disease

MAP2K5 [ENSP00000178640]

Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Synonyms:  MAP2K5,  MAP2K5p,  hMAP2K5,  A0A024R5X5,  A0A024R5Y2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM