DISEASES

Disease-gene associations mined from literature

Literature associating ERCC1 and oral cavity cancer

ERCC1 [ENSP00000013807]

DNA excision repair protein ERCC-1; [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4; Belongs to the ERCC1/RAD10/SWI10 family.

Synonyms:  ERCC1,  ERCC1p,  hERCC1,  A0A024R0Q6,  K7EJL2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM